I think blindness might be OK for a small period of time, but for anything long-term I'd hate it.
You're massively disabled. It's a struggle for you to just live and be self-sufficient, let alone anything else. You can't really write or draw, you can't read (or at least, not without electrical assistance), you can't enjoy television properly or the visual arts, you can't play video games, you can't drive, you can't really have a job...
I have no idea what the hell I'd do with the rest of my life if I couldn't see. Pretty much everything I do right now and plan to do in the future relies on my ability to see.
Not to hi-jack the thread or anything, but to clarify my earlier comment that might have been a little too blunt (or it was for Freeze at least), I reckon the question would be far more interesting if it included the full nine basic senses. The basic five would be a pretty obvious choice of taste from the point of view of self-survival, given that smell, touch, sight and hearing can all potentially save your life or prevent serious injury, or the second obvious choice of losing smell if you really want taste. There's not really a huge amount of serious choice there
The full spectrum of sight, hearing, touch, smell, taste, balance/acceleration, proprioception (being able to know where your hands etc are without looking), pain and temperature give a little bit more room for thought. The obvious one to lose would appear to be pain, but the side-effects of being unable to feel it are actually pretty horrific (and not necessarily in obvious ways either), so it overall it actually goes pretty high up the list for the ones you'd want to keep.